Zijie Zhang

State Key Laboratory for Conservation and Utilization of Bio-resource

Principal Investigator

       zijiezhang@ynu.edu.cn

Education

2020 - 2020   Postdoc at Department of Chemistry                                 The University of Chicago, IL, U.S.

2015 - 2020   Ph.D. in Genetics, Genomics and Systems Biology          The University of Chicago, IL, U.S.

2010 - 2014   B.S.   in Systems Biology                                                   Case Western Reserve University, OH, U.S.

Publications

36. A Hirsutella sinensis Alcohol Extract Exerts Bidirectional Immunoregulatory Effects by Regulating Macrophage Polarization

  Journal of Argricultural and Food Chemistry   2024

35. RNA mC oxidation by TET2 regulates chromatin state and leukaemogenesis

  Nature  2024

34. Biosafety and immunology: An interdisciplinary field for health priority

  Biosafety and Health  2024

33. Redox regulation of m6A methyltransferase METTL3 in β-cells controls the innate immune response in type 1 diabetes

Dario F. De Jesus, Zijie Zhang, Natalie K. Brown, Xiaolu Li, Ling Xiao, Jiang Hu, Matthew J. Gaffrey, Garrett Fogarty, Sevim Kahraman, Jiangbo Wei, Giorgio Basile, Tariq M. Rana, Clayton Mathews, Alvin C. Powers, Audrey V. Parent, Mark A. Atkinson, Sirano Dhe-Paganon, Decio L. Eizirik, Wei-Jun Qian, Chuan He & Rohit N. Kulkarni

  Nature Cell Biology  2024

32. Safety, immunogenicity and preliminary efficacy of a randomized clinical trial of omicron XBB.1.5-containing bivalent mRNA vaccine.

Xuanjing Yu# ; Wei Yang# ; Wei Li; Na Wan; Guanghong Yan; Zumi Zhou; Xiao Zhu; Wei Su; Yani Li,; Chenyu Xing; Sifan Duan; Houze Yu; Xinshuai Zhao; Chunmei Li; Taicheng Zhou*; Dingyun You*; Jia Wei*; Zijie Zhang*

  hLife  2024

31. Clinicopathological and immunological features of new onset kidney disease: a rare event after SARS-CoV-2 vaccination

Yue-Miao Zhang, Xing-Zi Liu, Zhao Zhang, Tai-Cheng Zhou, Xin Zhang, Hong-Yu Yang, Meng Tan, Nan Hu, Su-Fang Shi, Fang Wang, Rong Xu, Li-Jun Liu, Su-Xia Wang, Gang Liu, Fu-De Zhou, Ming-Hui Zhao, Hong Zhang, Ji-Cheng Lv*, Ya-Ping Zhang*, Zi-Jie Zhang*, Li Yang*

  National Science Review  2023

30. Reduction of mRNA m6A associates with glucose metabolism via YTHDC1 in human and mice

Kun Yang#, Juan Sun#, Zijie Zhang, Mengyao Xiao, Decheng Ren*, Song-Mei Liu*

  Diabetes Research and Clinical Practice  2023

29. Exon architecture controls mRNA m6A suppression and gene expression

P. Cody He#, Jiangbo Wei#, Xiaoyang Dou#, Bryan T. Harada#, Zijie Zhang, Ruiqi Ge, Chang Liu, Li-Sheng Zhang, Xianbin Yu, Shuai Wang, Ruitu Lyu, Zhongyu Zou, Mengjie Chen, Chuan He*

  Science  2023

28. Long-term and effective neutralization against omicron sublineages elicited by four platform COVID-19 vaccines as a booster dose

Yuemiao Zhang, Meng-Ting Luo, Qingqin Wu, Yun-Xia Wang, Xupu Ma, Guanghong Yan, Si-Hang Zhang, Yanli Chen, Na Wan, Liang Zhang, Dingyun You, Jia Wei*, Zijie Zhang*, Tai-Cheng Zhou* & Precise-CoVaccine study group

  Cell Discovery  2023

27. Large-Scale Chromosomal Changes Lead to Genome-Level Expression Alterations, Environmental Adaptation, and Speciation in the Gayal (Bos frontalis)

Yan Li*, Sheng Wang, Zhe Zhang, Jing Luo, Guo Liang Lin, Wei-Dong Deng, Zhifan Guo, Feng Ming Han, Li-Li Wang, Jie Li, Shi-Fang Wu, He-Qun Liu, Sheng He, Robert W Murphy, Zi-Jie Zhang, David N Cooper, Dong-Dong Wu, Ya-Ping Zhang*

  Molecular Biology and Evolution  2023

26. Dynamics of immune responses to inactivated COVID-19 vaccination over 8 months in China

Tianpei Shi, Mu-Xian Dai, Feng-Wei Liu, Jun Hu, Mu-Hua Feng, Gang-Xu Xu, Ya-Jing Wang, Li-Hong Zhang, Liang Zhang, Zijie Zhang*, Tai-Cheng Zhou*, Jia Wei*; on be half of the Precise-CoVaccine study group

  Journal of Infection  2023

25. Immunogenicity, durability, and safety of an mRNA and three platform-based COVID-19 vaccines as a third dose following two doses of CoronaVac in China: A randomised, double-blinded, placebo-controlled phase 2 trial

Yuemiao Zhang#, Xupu Ma#, Guanghong Yan#, Ying Wu#, Yanli Chen, Zumi Zhou, Na Wan, Wei Su, Feng-Wei Liu, Mu-Xian Dai, Mei Yang, Chunmei Li, Xuanjing Yu, Liang Zhang, Zhongfang Wang, Tai-Cheng Zhou, Dingyun You, Jia Wei*, Zijie Zhang* on behalf of the Precise-CoVaccine study group

  eClinicalMedicine  2022

24. Retrospective study of the immunogenicity and safety of the CoronaVac SARS-CoV-2 vaccine in people with underlying medical conditions

Chunmei Li*, Hanfang Bi, Zhenwang Fu, Ao Li, Na Wan, Jun Hu, Fan Yang, Tai-Cheng Zhou, Yupeng Liang, Wei Su, Tianpei Shi, Mei Yang, Rong Wang, Wanting Qin, Xuanjing Yu, Hong-Yi Zheng, Zumi Zhou, Yong-Tang Zheng, Jia Wei, Gang Zeng*, Zijie Zhang* & the Precise-CoVaccine study group

  Communications Medicine  2022

23. A third dose of inactivated SARS-CoV-2 vaccine induces robust antibody responses in people with inadequate response to two-dose vaccination

Taicheng Zhou*, Tianpei Shi, Ao Li, Lingzhi Zhu, Xinshuai Zhao, Naiyin Mao, Wanting Qin, Hanfang Bi, Mei Yang, Muxian Dai, Fengwei Liu, Rong Wang, Wei Su, Liang Zhang, Wenbo Xu, Jia Wei*, Zijie Zhang*

  National Science Review  2022

22. Immunosuppression impaired the immunogenicity of inactivated SARS-CoV-2 vaccine in non-dialysis kidney disease patients

Yue-Miao Zhang, Xing-Zi Liu, Miao-Miao Lin, Jin-Can Zan, Yi-Tong Hu, Xiang-Qiu Wang, Wen-Qi Wu, Tai-Cheng Zhou, Ji-Cheng Lv, Hong Zhang, Li Yang*, Zi-Jie Zhang*

  Journal of Infection  2022

21. The METTL5-TRMT112 N6-methyladenosine methyltransferase complex regulates mRNA translation via 18S rRNA methylation

Caraline Sepich-Poore, Zhong Zheng, Emily Schmitt, Kailong Wen, Zijie Scott Zhang, Xiao-Long Cui, Qing Dai, Allen C. Zhu, Linda Zhang, Arantxa Sanchez Castillo, Haiyan Tan, Junmin Peng, Xiaoxi Zhuang, Chuan He*, Sigrid Nachtergaele*

  Journal of Biological Chemistry  2022

20. Viral RNA N6-methyladenosine modification modulates both innate and adaptive immune responses of human respiratory syncytial virus

Miaoge Xue, Yuexiu Zhang, Haitao Wang, Elizabeth L. Kairis, Mijia Lu, Sadeem Ahmad, Zayed Attia, Olivia Harder, Zijie Zhang, Jiangbo Wei, Philip Chen,Youling Gao, Mark E. Peeples, Amit Sharma, Prosper Boyaka, Chuan He, Sun Hur, Stefan Niewiesk, Jianrong Li*

  Plos Pathogens  2021

19. M6A mRNA Methylation Regulates the Innate Immune Response in Human β-Cells

DARIO F. DE JESUS; ZIJIE ZHANG; NATALIE K. BROWN; JIANG HU; SEVIM KAHRAMAN; CLAYTON E. MATHEWS; ALVIN C. POWERS; MARK A. ATKINSON; DECIO L. EIZIRIK; CHUAN HE; ROHIT KULKARNI

  Diabetes  2021

18. Nonsegmented Negative-Sense RNA Viruses Utilize N6-Methyladenosine (m6A) as a Common Strategy To Evade Host Innate Immunity

Mijia Lu, Miaoge Xue, Hai-Tao Wang, Elizabeth L Kairis, Sadeem Ahmad, Jiangbo Wei, Zijie Zhang, Qinzhe Liu, Yuexiu Zhang, Youling Gao, Dominique Garcin, Mark E Peeples, Amit Sharma, Sun Hur, Chuan He, Jianrong Li*

  Journal of Virology  2021

17. LEAD-m6A-seq for Locus-Specific Detection of N6-Methyladenosine and Quantification of Differential Methylation

Yuru Wang, Zijie Zhang, Caroline Sepich-Poore, Lisheng Zhang, Yu Xiao, Chuan He*

  Angew Chem Int Ed Engl  2021

16. Genetic analyses support the contribution of mRNAN6-methyladenosine (m6A) modification to human disease heritability

Zijie Zhang#, Kaixuan Luo#, Zhongyu Zou, Maguanyun Qiu, Jiakun Tian, Laura Sieh, Hailing Shi, Yuxin Zou, Gao Wang, Jean Morrison, Allen C. Zhu, Min Qiao, Zhongshan Li, Matthew Stephens*, Xin He* & Chuan He*

  Nature Genetics  2020

15. Internal N6-methyladenosine modification controls the innate immune response to viral RNA

Miaoge Xue; Mijia Lu; Anzhong Li; Zijie Zhang; Chuan He; Jianrong Li*

  The Journal of Immunology  2020

14. N6-methyladenosine modification enables viral RNA to escape recognition by RNA sensor RIG-I

Mijia Lu, Zijie Zhang, Miaoge Xue, Boxuan Simen Zhao, Olivia Harder, Anzhong Li, Xueya Liang, Thomas Z. Gao, Yunsheng Xu, Jiyong Zhou, Zongdi Feng, Stefan Niewiesk, Mark E. Peeples, Chuan He & Jianrong Li*

  Nature Microbiology  2020

13. Evolution of a reverse transcriptase to map N1-methyladenosine in human messenger RNA

Huiqing Zhou, Simone Rauch, Qing Dai, Xiaolong Cui, Zijie Zhang, Sigrid Nachtergaele, Caraline Sepich, Chuan He* & Bryan C. Dickinson*

  Nature Methods  2019

12. RADAR: differential analysis of MeRIP-seq data with a random effect model

Zijie Zhang, Qi Zhan, Mark Eckert, Allen Zhu, Agnieszka Chryplewicz, Dario F. De Jesus, Decheng Ren, Rohit N. Kulkarni, Ernst Lengyel, Chuan He* & Mengjie Chen*

  Genome Biology  2019

11. Viral N6-methyladenosine upregulates replication and pathogenesis of human respiratory syncytial virus

Miaoge Xue, Boxuan Simen Zhao, Zijie Zhang, Mijia Lu, Olivia Harder, Phylip Chen, Zhike Lu, Anzhong Li, Yuanmei Ma, Yunsheng Xu, Xueya Liang, Jiyong Zhou, Stefan Niewiesk, Mark E. Peeples, Chuan He & Jianrong Li*

  Nature Communications  2019

10. m6A mRNA methylation regulates human β-cell biology in physiological states and in type 2 diabetes

Dario F. De Jesus#, Zijie Zhang#, Sevim Kahraman#, Natalie K. Brown, Mengjie Chen, Jiang Hu, Manoj K. Gupta, Chuan He* & Rohit N. Kulkarni*

  Nature Metabolism  2019

9. Single-base mapping of m6A by an antibody-independent method

Zhang Zhang, Li-Qian Chen, Yu-Li Zhao, Cai-Guang Yang, Ian A. Roundtree, Zijie Zhang, Jian Ren, Wei Xie, Chuan He, Guan-Zheng Luo*

  Science Advances 2019

8. Programmable RNA-Guided RNA Effector Proteins Built from Human Parts

Simone Rauch, Emily He, Michael Srienc, Huiqing Zhou, Zijie Zhang, Bryan C. Dickinson*

  Cell  2019

7. Transcriptome-wide Mapping of Internal N7-Methylguanosine Methylome in Mammalian mRNA

Li-Sheng Zhang, Chang Liu, Honghui Ma, Qing Dai, Hui-Lung Sun, Guanzheng Luo, Zijie Zhang, Linda Zhang, Lulu Hu, Xueyang Dong, Chuan He*

  Molecular Cell  2019

6. Small-Molecule Targeting of Oncogenic FTO Demethylase in Acute Myeloid Leukemia

Yue Huan, Rui Su, Yue Sheng, Lei Dong, Ze Dong, Hongjiao Xu, Tengfeng Ni, Zijie Scott Zhang, Tao Zhang, Chenying Li, Li Han, Zhenyun Zhu, Fulin Lian, Jiangbo Wei, Qiangqiang Deng, Yungui Wang, Mark Wunderlich, Zhiwei Gao, Guoyu Pan, Dafang Zhong, Hu Zhou, Naixia Zhang, Jianhua Gan, Hualiang Jiang, James C. Mulloy, Zhijian Qian, Jianjun Chen*, Cai-Guang Yang* 

  Cancer Cell  2019

5. N6-methyldeoxyadenosine directs nucleosome positioning in Tetrahymena DNA

Guan-Zheng Luo*, Ziyang Hao, Liangzhi Luo, Mingren Shen, Daniela Sparvoli, Yuqing Zheng, Zijie Zhang, Xiaocheng Weng, Kai Chen, Qiang Cui, Aaron P. Turkewitz & Chuan He *

  Genome Biology  2018

4. A dynamic N6-methyladenosine methylome regulates intrinsic and acquired resistance to tyrosine kinase inhibitors

Fei Yan#, Aref Al-Kali#, Zijie Zhang#, Jun Liu, Jiuxia Pang, Na Zhao, Chuan He*, Mark R. Litzow* & Shujun Liu*

  Cell Reasearch  2018

3. YTHDC1 mediates nuclear export of N6 - methyladenosine methylated mRNAs

Ian A Roundtree, Guan-Zheng Luo, Zijie Zhang, Xiao Wang, Tao Zhou, Yiquang Cui, Jiahao Sha, Xingxu Huang, Laura Guerrero, Phil Xie, Emily He, Bin Shen*, Chuan He*

  eLife  2017

2. Reducing mitochondrial reads in ATAC-seq using CRISPR/Cas9

Lindsey Montefiori, Liana Hernandez, Zijie Zhang, Yoav Gilad, Carole Ober, Gregory Crawford, Marcelo Nobrega* & Noboru Jo Sakabe*

  Scientific Reports  2017

1. Platelet-derived S100 family member myeloidrelated protein-14 regulates thrombosis

Yunmei Wang, Chao Fang, Huiyun Gao, Matthew L Bilodeau, Zijie Zhang, Kevin Croce, Shijian Liu, Toshifumi Morooka, Masashi Sakuma, Kohsuke Nakajima, Shuichi Yoneda, Can Shi, David Zidar, Patrick Andre, Gillian Stephens, Roy L Silverstein, Nancy Hogg, Alvin H Schmaier, Daniel I Simon*

  Journal of Clinical Investigation  2014