Systems Vaccinology 系统疫苗学

    我们致力于使用系统生物学研究范式解析疫苗免疫应答在人群中的多样性及其调控机制。疫苗是人类对抗感染性疾病最为经济有效的工具，新型疫苗技术与免疫学的发展，使得疫苗在肿瘤的免疫治疗方面也开始崭露头角。然而，在过去很长一段时间里，我们的疫苗发展总体上依赖于经验型研究；我们对疫苗与免疫系统的相互作用机制目前仍知之甚少。因此，我们致力于理解疫苗免疫应答的作用规律，并最终利用这些规律根据人群遗传和免疫特征、疫苗技术特点等参数规划免疫策略以及设计靶向免疫应答机制的新一代更安全更高效的疫苗。

We are dedicated to utilizing systems biology paradigms to elucidate the  regulatory mechanisms of diverse vaccine immune responses in populations. Vaccines is the most cost-effective tool for combating infectious diseases, and advancements in novel vaccine technologies and immunology have begun to highlight their potential in novel therapeutic potential such as cancer immunotherapy. However, for a long time, vaccine development has predominantly relied on empirical research; our understanding of the mechanisms underlying the interactions between vaccines and the immune system remains limited. Therefore, we are committed to understand the principles governing vaccine immune responses and ultimately leveraging these principles to design next-generation vaccines targeting genetic- and immune-mediated immune response mechanisms to achieve better safety and effectiveness in a wider range of people.