A girl stands firm upon a majestic dragon boat, the embodiment of ancient Chinese culture and resilience, with an outsized syringe, a symbol of novel vaccines technologies. The girl battles a tempest of COVID-19 virus that have loomed over the world, using biotechnology Scientists relentlessly navigate the stormy seas of infectious diseases, which signifies not only the ongoing efforts to combat the current pandemic but also the broader commitment to safeguarding public health through science and innovation. In this issue, Yu and his colleagues presented a randomized clinical trial of omicron XBB.1.5-containing bivalent COVID-19 mRNA vaccine in head-to-head comparison with other two mRNA vaccines encoding earlier variants, clarifying that newer variant-matched vaccine elicits an enhanced immune response against newly emerged variants. As we navigate through intricate molecular landscapes, vaccines heralds a new frontier in our enduring battle against existing and newly emerged pathogens, promising a future where health prevails.